DEF-Funded Retinitis Pigmentosa(RP) and Age-Related Macular Degeneration(AMD) Projects Converge with Promise

Two hallmark DEF-funded projects are converging, providing great hope for those facing vision loss from retinitis pigmentosa (RP) or age-related macular degeneration (AMD).

The first project, headed by UC Irvine researchers Drs. Henry Klassen and Jing Yang, concentrates on putting human retinal progenitor cells into the eyes of those with RP in order to rescue damaged retinal cells. That project is currently in Phase II clinical trials, progressing toward FDA approval.

                                                      Tissue-culture model

According to DEF Research Director Dr. Cristina Kenney, if the project is approved by the FDA for use with RP, the next question is: What other diseases might these retinal progenitor cells be used for? That’s where a second DEF-funded project comes in.

Kenney is working on a “personalized” cybrid cell model to screen agents that specifically target the mitochondria in AMD cells. To date, the researchers have different cybrid cell lines representing 60 different individuals with eye diseases. They are looking for novel mechanisms to protect AMD cells from dying.

Yang and Kenney are now working together to determine whether the retinal progenitor cells can be the agent that rescues AMD cybrids. “When we take the mitochondria from AMD patients and put them into healthy retinal cells, which makes cybrids, we have shown that these AMD cybrid cells will start to die. So we used that model to ask the question: How do we rescue them?” Kenney says.

Kenney and Yang developed a tissue culture model, where the retinal progenitor cells are grown in one part of a chamber, and the AMD cybrids are grown in another part of chamber, surrounded by culture medium. There is a porous separator between the two chambers through which the cells can communicate.

 “We are finding that the retinal progenitor cells produce a factor that protects the AMD cybrids,” Kenney says. “This provides promising evidence that these proprietary retinal progenitor cells that are being tested for treating RP also may be helpful in AMD patients.”

“DEF has been supporting both these retina-related projects for quite some time, and it’s very exciting to see them coming together to potentially treat both RP and AMD.”

To help support this sight-saving research, please donate to the Discovery Eye Foundation by clicking button below.

July is UV Safety Awareness Month

According to the American Academy of Ophthalmology, studies show that long-term exposure to bright sunlight may increase the risk of cataracts and growths on the eye, including cancer.

UV rays reflected off sand and water can cause eyes to sunburn, potentially resulting in temporary blindness in just a few hours. In support of UV Safety Month this July, the American Academy of Ophthalmology reminds the public of the importance of shielding eyes from the sun’s harmful rays with 100% UV-blocking sunglasses and broad-brimmed hats.

Here are some tips from the American Academy of Ophthalmology:

  • Don’t focus on color or darkness of sunglass lenses: Select sunglasses that block UV rays. Don’t be deceived by color or cost. The ability to block UV light is not dependent on the price tag or how dark the sunglass lenses are.
  • Check for 100 percent UV protection: Make sure your sunglasses block 100 percent of UV-A rays and UV-B rays.
  • Choose wrap-around styles: Ideally, your sunglasses, either the lenses of the frame, should wrap all the way around to your temples, so the sun’s rays can’t enter from the side.
  • Wear a hat: In addition to your sunglasses, wear a broad-brimmed hat to protect your eyes.
  • Don’t rely on contact lenses: Even if you wear contact lenses with UV protection, remember your sunglasses.

  • Don’t be fooled by clouds: The sun’s rays can pass through haze and thin clouds. Sun damage to eyes can occur anytime during the year, not just in the summertime.
  • Protect your eyes during peak sun times: Sunglasses should be worn whenever outside, and it’s especially important to wear sunglasses in the early afternoon and at higher altitudes, where UV light is more intense.
  • Never look directly at the sun. Looking directly at the sun at any time, including during an eclipse, can lead to solar retinopathy, damage to the eye’s retina from solar radiation.
  • Don’t forget the kids: Everyone is at risk, including children.
  • Protect their eyes with hats and sunglasses. In addition, if possible, try to keep children out of the sun between 10 a.m. and 2 p.m., when the sun’s UV rays are the strongest.

In addition to the proper safety eyewear, regular eye exams for early detection and treatment of eye conditions and diseases are essential to maintaining good vision at every stage of life.

According to the American Academy of Ophthalmology, children with a family history of childhood vision problems should be screened for common childhood eye problems before the age of 5. If eye problems such as visual changes, pain, flashes of light, seeing spots, excessive tearing and excessive dryness occur, they should see an eye doctor. Adults between the ages of 40 to 65 should have an eye exam every two years. Adults over the age of 65 should have an eye exam at least every one to two years.

 

Your Vision: Getting Fit Post-Pandemic

The past year has taken a toll on the physical and mental health of millions of people.  While we were rightly focused on slowing the spread of the pandemic, widespread shutdowns brought about a more sedentary, inactive lifestyle, which has led to increased weight gain and worsened mental health for many.  As we look ahead and as more people receive the vaccine, it is time to start reprioritizing physical activity and placing much needed attention on our health.

It’s no secret that exercise is the best way to get in shape and to prevent serious health conditions, especially after this pandemic. But did you know that you can actually exercise your way to healthy eyes too?  By eating a healthy diet and exercising regularly, you can help prevent eye conditions linked to obesity and being out of shape.

Below are a few tips on how to get your fitness regimen back on track.

  • Set Goals – The first step to getting back in shape is deciding what you want to achieve. Take a personal inventory and write a contract with yourself, put it someplace where you can see it every day.
  •  Start Small – Getting too ambitious when planning goals can set you up for failure. Instead, ease into the changes. A lot of people get discouraged because they try to change their whole routine immediately.
  • Build Momentum – Mini daily victories create a sense of accomplishment.  A few daily successes will create a snowball effect.  Add more challenges, then a few more and that’s what will keep the momentum going.
  • Enjoy Your Workout – The best way to stick with an exercise routine, is enjoying it. You’re more likely to stay on schedule and exercise more often if you enjoy what you are doing.  Hiking, swimming, boxing, dance or yoga are great options—and create atmosphere that’s inviting.
  • Stretching Matters – It preps your muscles for exercise and cools them down after, guarding against injury. Stretching also improves your posture.
  • Invest In Equipment – You don’t need to spend a lot of money—a few weights are enough to deliver results.  Even minimal equipment allows for more intense and effective workouts.
  • Make it a Habit – Exercise should be part of your daily routine, it should be as normal as showering or brushing your teeth.
  • Get A Workout Buddy – If you can’t recruit a family member or friend, join a Zoom class or an outdoor club. 

Stay active, get plenty of exercise and keep a healthy diet. When you’re tempted to slack off, or quit exercising all together—give yourself a day off to relax.  Just remember how terrific you’ll look and feel when you keep moving.

You’ll probably agree it’s worth working out a few minutes each day to reap the rewards of good health and great vision!

 

Click here for Eye Healthy Recipes.

May-Healthy Vision Month

When it comes to our health, we may visit our doctors and nurses regularly to make sure our bodies are healthy. But what about our eyes? They’re not always top of mind, but they’re just as important! May is Healthy Vision Month, an observance coordinated by the National Eye Institute to motivate Americans to make their eye health a priority and educate them about steps they can take to protect their vision.

Here are a few ways you can help protect your vision

  • Get an annual comprehensive dilated eye exam.
  • Know your family’s eye health history. It’s important to know if anyone has been diagnosed with an eye disease or condition, since some are hereditary.
  • Eat right to protect your sight: In particular, eat plenty of dark leafy greens such as spinach, kale, or collard greens, and fish that is high in omega-3 fatty acids such as salmon, albacore tuna, trout, and halibut. Visit Eye Cook for eye healthy recipes.
  • Maintain a healthy weight.
  • Wear protective eyewear when playing sports or doing activities around the home, such as painting, yard work, and home repairs.
  • Quit smoking or never start.
  • Wear sunglasses that block 99 -100 percent of ultraviolet A (UVA) and ultraviolet B (UVB) radiation.
  • Wash your hands before taking out your contacts and cleanse your contact lenses properly to avoid infection.
  • Practice workplace eye safety.

Taking care of your eyes also may benefit your overall health. People with vision problems are more likely than those with good vision to have diabetes, poor hearing, heart problems, high blood pressure, lower back pain and strokes, as well as have increased risk for falls, injury and depression.

In addition to your comprehensive dilated eye exams, visit an eye care professional if you have

  • Decreased vision.
  • Eye pain
  • Drainage or redness of the eye
  • Double vision
  • Diabetes
  • Floaters (tiny specks that appear to float before your eyes)
  • Circles (halos) around light sources or if you see flashes of light

For this Healthy Vision Month, take care of your eyes to make them last a lifetime.

How to Prevent Eye Strain While Working From Home

Working from home has become the new normal for many Americans during this pandemic.  Most are happy without the commute, although working outside the office and in all sorts of strange places, such as bedrooms, backyards, living rooms, has become common place. We’ve had to learn how to work remotely, which in turn means spending a lot more time using computers and smartphones.

Moving out of properly-lit classrooms and offices – and away from ergonomically correct desks – can have long-term effects on our eyes.  Excessive time at a computer screen under the best conditions can lead to symptoms of eye strain.

Eye Strain Symptoms include:

  • Headaches
  • Blurred vision
  • Uncomfortable dry eyes
  • Neck and shoulder pain

To help avoid eye strain, here are few tips for working from home:

  • Record time spent on screens – Most adults age 18 and older spend at least 13 hours each day using digital devices. Extended screen time can cause discomfort and vision difficulties. When working from home, you may lose track of how much time you’re on your computer or smartphone.  So keep track of the hours you use devices. That way, you’ll be aware of the demand you’re placing on your eyes.
  • Rest and blink your eyes – Researchers found that over 30% of people using digital devices rarely take time to rest their eyes. Just over 10% say they never take a break, even when working from home. The eye muscles get overworked and don’t get a chance to relax and recover. Experts suggest the 20-20-20 rule; every 20 minutes, focus your eyes and attention on something 20 feet away for 20 seconds.  You can also get up and walk around for a few minutes.

 

  • Reduce exposure to blue light – In the spectrum of light, blue is more high energy and close to ultraviolet light. So, if you use screens throughout the day, ask your eye doctor about the value of computer glasses that block blue light. Reducing exposure to blue light may help lessen vision problems.  At home, using digital devices until bedtime can overstimulate your brain and make it more difficult to fall asleep. Eye doctors recommend no screen time at least one to two hours before going to sleep.

  

  • Sit up straight – Proper posture is important. Your back should be straight and your feet on the floor while you work. Elevate your wrists slightly instead of resting them on the keyboard.

 

 

  • Proper lighting – A setting that’s too bright (sunny backyard) or too dim (cavernous basement) can cause eye strain and headaches. Your screen should be bright enough that you don’t need to squint. A screen shield can help reduce glare.

 

  • Set up monitor properly – Make sure your computer screen is about 25 inches, or an arm’s length, away from your face. The center of the screen should be about 10-15 degrees below eye level.  Cut glare by using a matte screen filter. You can find them for all types of computers, phones, and tablets.  Increase font size or set the magnification of the documents you are reading to a comfortable size.

 

  • Consider computer glasses –For the greatest comfort at your computer, you might benefit from having your eye doctor modify your eyeglasses prescription to create customized computer glasses. This is especially true if you normally wear distance contact lenses, which may also become dry and uncomfortable during extended screen time.  Computer glasses also are a good choice if you wear bifocals or progressive lenses, because these lenses generally are not optimal for the distance to your computer screen.
  • Create Technology-Free Zones – These tips can help reduce eye strain when you’re forced to look at screens all day, creating technology-free zones in certain areas of your home, like the bedroom or bathroom. If you spend the entire day working on the computer, getting in bed and scrolling through social media until you fall asleep won’t do your eyes any favors.

Once you’re done for the day, truly unplug. Read a book or spend some quality time with family members without your phone.

 

  • Get an Eye Exam – If you have tried all these tips and eye strain is still an issue, it might be time to see an eye care professional to schedule an eye exam.  The exam may even detect underlying issues before they becomes worse.

 

 

 

 

 

Low Vision Awareness Month

Low vision affects millions of Americans — including many older adults. People with low vision aren’t blind, but because of their vision loss, they may not be able to do everyday tasks like driving or reading even with glasses.

What is Low Vision?

When your eyesight is impaired to the degree that you struggle with daily tasks like reading or cooking – or that you have difficulty recognizing faces, you may have a medical condition referred to as low vision. Someone with low vision can’t simply put on a pair of glasses or contacts and see well; this condition is beyond the typical loss of vision that occurs with aging.

Individuals experiencing low vision can struggle with maintaining independence; hobbies, reading and even socializing may become challenging as vision loss progresses. Because of the impact low vision can have on your life, it is important to have your eyes checked by a low vision specialist if you have any concerns.

Since it is unusual to be able to restore vision once it is lost, screenings can help preserve the vision you have and help you access adaptive lenses and devices if you need them. While there is not a cure for low vision, your specialist can help you adapt and if needed, create a vision rehabilitation program designed to meet your specific needs.

Low vision is often caused by one of these conditions:

  • Age-related macular degeneration (AMD) –AMD is a progressive eye condition affecting as many as 15 million Americans. The disease attacks the macula of the eye, where our sharpest central vision occurs, affecting reading, driving, identifying faces, watching television, safely navigating stairs and performing other daily tasks. Although it rarely results in complete blindness, it robs the individual of all but the outermost, peripheral vision, leaving only dim images or black holes at the center of vision. Read More (link to DEF website)
  • Diabetes– Diabetic retinopathy is the most common diabetic eye disease and a leading cause of blindness in American adults caused by changes in the blood vessels of the retina.

In some people with diabetic retinopathy, blood vessels may swell and leak fluid or blood inside the eye. In other people, abnormal new blood vessels grow on the surface of the retina. The retina is the light-sensitive tissue at the back of the eye. A healthy retina is necessary for good vision. Read More (link to DEF website)

  • Glaucoma– glaucoma is a disease that causes damage to the major nerve of the eye called the optic nerve, a part of the central nervous system that carries visual information from the eye to the brain.

The eye experiences a gradual increase of intraocular pressure (IOP) due to an imbalance of the fluid produced in the eye and the amount of fluid drained. Over time, elevated IOP can cause vision loss. The most common form of glaucoma is primary open angle glaucoma which affects about 3 million Americans. However, there are other types including narrow angle, congenital, normal tension, and secondary glaucoma. (link to DEF website)

  • Injury to the eye can also be a cause

Regular eye exams are essential for all adults; it is recommended that adults over the age of 60 have eye exams each year. For older adults, diabetics and anyone with the risk factors above, a visit with a low vision specialist may be warranted as well. This specialist differs from a conventional optometrist and is trained to detect low vision and offer solutions to help you retain or regain independence and the ability to do things you enjoy again.

While Low Vision Awareness Month is the ideal time to learn about this condition and about the risk factors you could be facing, you should get in touch with a low vision specialist any time you have concern about your eyesight. Any time you notice a change in vision, if you receive a new diagnosis or have one or more of the risk factors detailed above you should schedule an appointment right away.

Low Vision Resources from the National Eye Institute

It can be hard to describe low vision. Visit our website Vision Simulation to see what life is like with common causes of low vision, like age-related macular degeneration, diabetic retinopathy, and glaucoma.

Thanksgiving Dinner for your EYES!

Thanksgiving is almost here; a meal that nourishes the family bonds and traditions.  It’s the one time of the year where you can guarantee your eyes will be bigger than your stomach. This meal also has another added bonus — almost every item on the Thanksgiving table is healthy for your eyesight!

Here are several of the most popular Thanksgiving dishes and their corresponding benefits to your eye health:

Turkey –

No Thanksgiving is complete without a turkey, roasted golden brown and stuffed with fresh vegetables and herbs. Turkey is loaded with zinc and B-vitamin niacin, which helps prevent the formation of cataracts. Cataracts are the leading cause of vision loss in the United States, so gobble up!  You are “preventing” cataracts with every bite.

 

Spinach, Green Bean Casserole, Asparagus and Brussel Sprouts –

These foods and other leafy greens are loaded with lutein and zeaxanthin, two nutrients that protect the retina, which may also help reduce the risk of cataracts and macular degeneration.  Healthy Green Bean Casserole Recipe

 

Sweet Potatoes –

Sweet potatoes are full of Beta-carotene, which is a carotenoid and antioxidant that promotes night vision and overall good eyesight. Sweet potatoes are also loaded with vitamins C and E. Diets that are rich in these vitamins can help prevent or delay the development of cataracts and macular degeneration. Mashed Sweet Potatoes Recipe

 

Cranberry Sauce –

Cranberries contain bioflavonoids, a large class of antioxidants. Bioflavonoids are found in the pulp, skin and rinds of foods that contain vitamin C. Both flavonoids and vitamin C help protect the eyes from free radical damage caused by pollution and the body’s normal metabolic processes.

 

Pumpkin Pie –

Pumpkin is one of the best sources of vitamin A, so pumpkin pie is an eye-healthy dessert. In fact, one cup of cooked, mashed pumpkin contains more than 200 percent of the recommended daily intake of Vitamin A. Vitamin A provides nourishment and protection to the eye’s lens, cornea and macula (part of the retina), so it improves night vision. 

 

A diet that’s full of the right nutrients is a great start to keeping your eyes healthy, but don’t forget that regular eye exams are equally important! We hope you enjoy a happy and delicious Thanksgiving with family and friends.

*For more eye healthy recipes click here EYE COOK

What To Expect On Your Next Visit To Your Eye Care Practitioner During COVID-19 Pandemic

Taking care of your health is critical and you may have concerns related to eye health as a result of the COVID-19 pandemic. The offices of Ophthalmologists and Optometrists are resuming the delivery of comprehensive eye and vision care and implementing new protocols to provide care in a safe and healthy environment.

While changes vary from state-to-state as well as individual practice locations, patients should expect that their eye doctors, like all medical professionals, are adhering to federal, state and local health directives regarding infection prevention measures and implementing appropriate safety procedures to reduce the risk of COVID-19 transmission within the office. These not only include strict protocols for cleaning and sterilization, but measures to effectively manage patient flow and encourage physical distancing. Patients should expect screenings for symptoms of COVID-19 and taking patients’ temperature upon their arrival at the facility, limiting the number of guests allowed in waiting rooms and requiring everyone to wear a facemask and/or gloves before entering the office.

Prior to the appointment, you should be asked a series of questions such as whether you have been diagnosed with COVID-19, whether you have been exposed to anyone who has an active COVID infection, and whether you have any of the typical symptoms of a COVID-19 infection including fever, cough, shortness of breath, or some impairment of your sense of taste or smell. You may also be asked about recent travel history. If there is a concern that you may have COVID-19 infection, then the appointment may be rescheduled to a later date.

Once you get to the office, you will be interviewed again to see if you have any symptoms suggestive of COVID-19 infection. You may be asked to have your temperature taken with a non-contact thermometer and to wash your hands or scrub your hands with hand sanitizer before entering the office. You may be asked not to bring any family members or assistants with you.

Every patient (and anyone accompanying the patient) is required to wear a mask, and the mask must be worn properly, covering both the nose and mouth. The mask must be worn through the entire visit, and conversations with the doctor or staff will be limited. The tests that are used to monitor glaucoma may be performed with modified protocols to minimize the time you spend at the office.

How to Prepare for Your Eye Doctor Visit

  • Don’t go if you’re feeling sick. If you wake up with a cough or a sore throat, it’s probably best to reschedule your appointment and call your primary physician. Your routine eye exam can wait. Don’t be surprised if someone takes your temperature upon arrival to ensure safety for everyone.
  •  Fill out forms in advance. If possible, fill out your intake forms online before your appointment. This will limit your face-to-face contact and your overall time within the office. Any additional information that’s requested by your doctor can also be done over the phone.
  • Follow social distancing guidelines. There may be new procedures in place to help with social distancing, from markers on the ground indicating where to stand, to a limited number of people allowed in certain areas. Depending upon the office location, you may need to call from your car to check in. Every office is different, so be sure to check with your doctor’s office about their requirements.
  • Go alone to your appointment. Most offices are only allowing the patient to enter the office, with the exception of those who require a caregiver or a guardian to attend the appointment with them. This limits the amount of people going in and out of the office, and helps maintain a more sterile, clean environment.
  • Wear a mask to your appointment. Depending on your state, a mask may either be mandated or highly recommended when you are in public places. The Centers for Disease Control and Prevention highly advises people to wear a mask covering their nose and their mouth in order to help stop the spread of COVID-19.

As your eye care doctors begin reopening and operations proceed under a “new normal,” your ophthalmologist and/or optometrist are working to ensure the continued safe delivery of essential eye care during the COVID-19 pandemic.

To know exactly what to expect during your appointment, call your doctor’s office to find out how to best prepare for your visit.

Beauty is in the Eyes of the Beholder

I love the idea that beauty is in the eyes of the beholder. It reminds us that individuals can make choices about what they perceive to be true beauty.

Let’s consider art… one person’s beautiful can be another person’s junk. If beauty is in the eyes of the beholder, the question is – are we taking the time to appreciate all that surrounds us? From Mother Nature’s unlimited panoplies of possibilities to the innocent smile of a child, beauty is the catalyst that makes being alive the greatest of all human adventures.

I am sure you’ve heard the phrase “stop and smell the roses,” so why not take the time to stop and observe the beauty your eyes can behold.

The Discovery Eye Foundation is working every day to preserve your vision and give all of us the chance to see what’s truly beautiful and treasure it.  All you have to do is open your eyes and take a look.

Louis Armstrong said it well:

I see trees of green and red roses too.
I see them bloom for me and you.
And I think to myself,
what a wonderful world.

You’re right Louis… it is a wonderful world if we all just keep appreciating the beauty that’s out there for all of us.

 
Donate today to help support the Discovery Eye Foundation! 

DonateNow

Tom Sullivan
DEF’s Ambassador of Vision
sullivanvision.com

 

June is Cataract Awareness Month

June is Cataract Awareness Month. This is a time to raise cataract awareness and help to educate people about one of the leading causes of treatable vision loss in the United States. There are 24 million Americans over the age of 40 who are affected by cataracts, so it seems fitting that an entire month should be dedicated to cataract education and awareness.

A cataract is a clouding of the eye’s lens, which blocks or changes the passage of light into the eye. The lens of the eye is located behind the pupil and the colored iris, and is normally transparent. Vision may become blurry or dim because the cataract stops light from properly passing through to the retina. Generally, a cataract does not cause pain, redness or tearing, but does cause increasing difficulty in seeing clearly.

 

Here is an overview of Cataracts:

View Video

 

Cataract symptoms:

  • Cloudy
  • Night vision
  • Glare
  • Halo
  • New glasses
  • Yellow tint
  • Double vision

Some Risk factors for cataracts include:

  • Older age
  • Intense heat or long-term exposure to UV rays from the sun
  • Certain diseases, such as diabetes
  • Inflammation in the eye
  • Hereditary influences
  • Long-term steroid use
  • Eye injuries
  • Eye diseases
  • Smoking

Cataracts can be easily diagnosed and visiting your eye doctor regularly is important in helping protect your eyes from further damage. An annual eye exam is recommended for everyone over the age of 60, and bi-annual exams for adults between 41-60 years to check for developing eye or vision problems.

 

There are a few treatment options, below is one of the newest options:
View Video

 

There is no proven way to prevent age-related cataracts. However, choosing a healthy lifestyle can slow the progression of cataracts. Some ways to delay the progression of cataracts include avoiding smoking, reducing exposure to UV rays, eating healthy foods, and wearing proper eye protection to avoid eye injury.

For more information and where you can find support for Cataracts click here .