Mitochondrial Revolution: New Hope for AMD and Aging Diseases

How many times have we heard: “This field has been thoroughly studied, and we know all there is to know; there is no reason to continue investigating, because there is nothing more to find out on the subject”? This has been the attitude of some researchers with respect to the importance of mitochondria and diseases. For more than 50 years, we have known that mitochondria, which are the “batteries” of the cell, are critical for energy production. But many believed they did not have other major roles in the health of the cell, so when it came to developing drugs against diseases, mitochondria were overlooked.

That idea has now been turned on its head.

Mitochondria

Led by Discovery Eye Foundation (DEF) Research Director Dr. Cristina Kenney, the Mitochondria Research Group believed that, to really discover something new, you have to look in novel areas. This group has done just that. Using the transmitochondrial cybrid model, which are cell lines with identical nuclei, but with each line containing mitochondria from a different person, they have shown that the mitochondria have major regulation powers over cell behavior and expression of disease-related pathways. This is significant, because the mitochondria then become a target for therapies to combat diseases.

Kenney’s group is investigating various drugs and substances that will keep the mitochondria healthy and, ultimately, improve the health of the retinal cells in age-related macular degeneration (AMD). But it does not stop there. This same approach to developing mitochondria-targeting drugs is being pursued for drugs to treat Parkinson’s disease, Alzheimer’s disease, leukemia, various cancers, heart failure, thrombosis, stroke, diabetic retinopathy, Leber hereditary optic neuropathy, and even liver toxicity from acetaminophen.

The continued support from DEF, especially in the early stages of the mitochondria research, has fostered a new area to be opened up, specifically for AMD and diabetic retinopathy. In turn, this has allowed new collaborations among Kenney and researchers from the eye field, and laboratories studying the brain and neurodegeneration, cardiology, cancer therapies and methods to reduce side effects from cancer drugs. Kenney’s discoveries using cybrids have revolutionized the field of mitochondrial research, showing that mitochondria have wide-ranging biological effects never imagined and opening up the field of mitochondrial therapy to careful investigation.

You can help make a difference by supporting DEF’s sight saving research. Help our researchers advance AMD research by donating today! 

DonateNow

 

Lauren HauptmanLauren Hauptman
Lauren Hauptman Ink

My Best Gift!

The other day my daughter Blythe asked me which Christmas I consider to be my favorite.  I had to think a minute, because as a family, the Sullivan’s have had some great ones.  I was about to say the first time you and your brother Tom were old enough to really get into Santa, being absolutely sure that the fat man brought your presents right down the chimney.  I was about to say that, and then I remembered. 

The greatest Christmas I ever enjoyed was a ski trip in Winter Park, Colorado, when our children were teenagers and our friend, the marvelous Betty White, joined us for a Christmas Eve sleigh ride none of us will ever forget.  The night was perfect.  It had snowed earlier that day, and the air had a feeling of Christmas that you could almost taste.  Oh, sure, it was cold, but we were bundled up under tons of blankets as two beautiful Clydesdale horses with bells jingling took us through the woods to a magical barn where dinner would be served and carols sung. 

It was on the way home that my Christmas was made complete.  We had stopped to let the horses breathe, and everyone was quiet, just allowing the feeling of togetherness envelope us in that special night.  It was Betty who broke the silence. 

“Tom,” she said almost to herself, “I wish I may, I wish I might, let you see the stars tonight.  I feel like we could almost reach up and touch them.  That’s how bright and close they are.  I guess when you’re this high in the Rocky Mountains, it just feels like they’re right here.”

I could hear how much my friend wanted me to see such a heavenly display, but we both knew that could never happen.  I have no complaint about being blind, no one could have a better life, but I would be lying if I didn’t admit at this holiday season that I’d love to be able to take it all in, all the special sights of Christmas. 

Every day in laboratories around this country, researchers are working to solve the multiple eye diseases that make it impossible for millions of people to see the joys of Christmas.  At this holiday season, my best gift would be that all of us donate to the Discovery Eye Foundation with its goal to preserve vision and eradicate blindness around the world.  During this season of giving, may your hearts be light and your sight be bright. 

Merry Christmas!

Tom Sullivan
DEF’s Ambassador of Vision
sullivanvision.com

 

Keep Your Eyes Comfortable During the Cold Winter Months

Harsh weather conditions can reduce the natural moisture in your eyes and the irritation usually results in a burning or itching sensation that often leads to rubbing or scratching your eyes which can worsen the symptoms. Sometimes it feels like there is a foreign object in your eye and for some, dry eyes can even cause excessive tearing, as your eyes try to overcompensate for their lack of protective tears. Prolonged, untreated dry eyes can lead to blurred vision as well. Between the harsh winter winds outside and the dry heat radiating inside, our eyes are very quickly irritated and dried in the winter months.  The result is itchy, dry eyes that may cause pain, blurred vision, a burning sensation, or even watery vision as our eyes try to compensate for the dryness.

What Are The Symptoms?

  • Uncomfortable, stingy, burning or scratchy feeling.
  • Stringy mucus in or around your eyes
  • Increased eye irritation from smoke or wind
  • Eye fatigue
  • Sensitivity to light
  • Eye redness
  • A sensation of having something in your eyes
  • Difficulty wearing contact lenses
  • Periods of excessive tearing
  • Blurred vision, often worsening at the end of the day or after focusing for a prolonged period

10 TIPS TO KEEP YOUR EYES COMFORTABLE DURING THE WINTER MONTHS

Whatever the symptoms, dry eyes can cause significant discomfort during the long winters and relief can seriously improve your quality of life.

  1. To keep eyes moist, apply artificial tears/eye drops a few times a day. If you have chronic dry eyes, speak to your eye doctor about the best product for your condition.
  2. Drink a lot of fluids – keeping your body hydrated will also help maintain the moisture in your eyes.
  3. If you spend a lot of time indoors in heated environments, use a humidifier to add some moisture back into the air.
  4. Try to situate yourself away from sources of heat, especially if they are blowing. While a nice cozy fire can add to the perfect winter evening, make sure to keep your distance so dry eyes don’t ruin it. 
  5. Staring at a computer or digital device for extended amounts of time can further dry out your eyes. If you spend a lot of time staring at the screen, make sure you blink often and practice the 20/20/20 rule – every 20 minutes, look 20 feet away for 20 seconds. Use artificial tears often to lubricate eyes during long periods of using your eyes.
  6. Avoid air blowing in your eyes. Don’t direct hair dryers, car heaters, air conditioners or fans toward your eyes. In your car, direct heat to floor vents and away from your eyes once your windshield is defrosted.
  7. Stop smoking and avoid smoky environments.
  8. Don’t rub your eyes! This will only increase irritation and can also lead to infections if your hands are not clean.
  9. Give your eyes a break and break out your glasses. If your contact lenses are causing further irritation, take a break and wear your glasses for a few hours or days. Also talk to your optometrist about switching to contacts that are better for dry eyes.
  10. Protect your eyes. If you know you are going to be venturing into harsh weather conditions, such as extreme cold or wind, make sure you wear protection. Try large, 100% UV protective eyeglasses and a hat with a visor to keep the wind and particles from getting near your eyes. If you are a winter sports enthusiast, make sure you wear well-fitted ski goggles.

If you find that after following these tips you continue to suffer, contact your eye doctor.

The Human Drama

All of us are players in the human drama, and there are moments when we get to observe it up close and very personal. I was in Chicago, preparing to speak in an ophthalmology practice. As I often do, I arrived early to sit in the waiting area and work to get a feel for the energy and style of the practice. I didn’t mean to overhear their conversation, but as I listened, I was deeply touched by their love and in that moment, their fear.

I learned that Charlie was 88 and Rose was 86. I am sure they were holding hands as Rose was saying “Oh, Charlie, I am so sorry about the falls I have had. I just can’t see the step from the kitchen into the family room.”

Charlie tried to comfort her. “It’s alright Dear, the Doctor will give us the answers, and I am sure you’ll be better.”

I didn’t speak to Charlie over the next 40 minutes believing that I would be intruding but sure that he was living every second of the exam going on just a few steps away.

When Rose exited the Doctor’s office, she was supported by the Doctor and a Tech who must have been holding her up because she collapsed into her husband’s arms.

“I’m sorry,” she kept saying.  “I am sorry Charlie. It’s Macular Degeneration.  And, the Doctor says there’s very little he can do for me.”

I could hear Charlie rubbing his wife’s shoulders and telling her that everything would be alright. But, Rose kept saying “I know we’ll have to sell the house and move into something smaller, and I am going to be blind Charlie. Blind.”

Moments like this are happening across the country in ophthalmology and optometry practices every day. 30% of adults, age 60 and older, suffer from this horrible disease, and only through research will answers be found.

The Discovery Eye Foundation is committed to finding those difficult answers and making it possible for people like Rose to see the faces of loved ones for many years to come.

 

Tom Sullivan
DEF’s Ambassador of Vision
sullivanvision.com

 

September is Healthy Aging Month

 

Today, people are living longer than ever before so it’s important to be proactive and take responsibility for your health as you age.  

Like any other organ in your body, your eyes do not stay the same as you get older. Vision changes are normal with age but vision loss and blindness are not.  Older adults are at higher risk for certain eye diseases and conditions, including age-related macular degeneration, cataract, diabetic retinopathy, glaucoma, dry eye, and low vision.  To continue to enjoy healthy vision as you advance in years, it’s important to have a comprehensive dilated eye examination with an ophthalmologist or optometrist on a regular basis.

Here are some other tips to maintain healthy vision now and as you age:

  • Eat a healthy, balanced diet. Fruits and vegetables can help keep your eyes healthy. Visit our website for healthy eye recipes, click here Eye Cook.

 

 

  • Maintain a healthy weight. Being overweight increases your risk for diabetes. By exercising regularly, you can help keep your body healthy and prevent vision loss. 

 

 

 

  • Don’t smoke. Smoking increases your risk for age-related macular degeneration, cataract, and other eye diseases and conditions that can damage the optic nerve.

 

 

 

  • Wear protective eyewear when outdoors. Protecting your eyes from the sun’s ultraviolet rays when you are outdoors is vital for your eye health.  Wearing sunglasses that block 99 to 100 percent of both UV-A and UV-B radiation.

 

 

  • Know your family history.  Talk to your family members about their eye health history. It’s important to know if anyone has been diagnosed with a disease or condition since many are hereditary, such as glaucoma, macular degeneration, and diabetes . This will help determine if you are at higher risk for developing an eye disease or condition.

 

  • Consider a multivitamin. Vitamins C, E and the mineral zinc have been shown to promote eye health.  Vitamins with Lutein and Zeaxanthin have been known to help patients with moderate to severe age-related macular degeneration.

 

  • Give your eyes a rest.  If you spend a lot of time at the computer or focusing at any one distance, you sometimes forget to blink, resulting in dryness and eye fatigue.  Every 20 minutes, look away about 20 feet in front of you for 20 seconds. This can help reduce eyestrain. Consider using a lubricant eye drop during long periods of intense eye use and rest your eyes for 5 minutes.

 

You can’t stop time, but you can take care of your eyes so that they remain healthy as you age. Having a healthy vision can be possible at any age! 

A New Commitment to Vision

Meet Tom Sullivan – DEF’s Ambassador of Vision

Over the last 40 years, I’ve been committed to working on behalf of blind children and their families.  My involvement has spanned the entire gamut of participation – from direct involvement in the classroom and counseling parents to hosting organized 10K races and celebrity golf tournaments that carried my name.  In that time, my wife and I raised just over $8 million thanks to the generosity of so many people.  Though my commitment to this cause has not changed, I’ve chosen to take on a new challenge that has in every way re-energized my passion. 

I’ve recently become the Ambassador of Vision for the Discovery Eye Foundation (DEF), a remarkable organization that funds cutting edge research that I believe someday will eliminate many forms of blindness.  The principle reason for my enthusiastic commitment is largely due to the fact that DEF directly funds researchers and avoids institutional restrictions.

As of this blog, DEF is engaged in ongoing efforts to understand 5 main eye diseases – Retinitis Pigmentosa, Macular Degeneration, Keratoconus, Diabetic Retinopathy, and Glaucoma.  I can honestly tell you that breakthroughs are not only on the horizon, but in many cases they are imminent.  Over the weeks and months I’ll be telling you much more, specifically about our individual research projects.  

Any help you may choose to give on behalf of people struggling with vision loss will be deeply appreciated. I look forward to having many of you join my fight for sight. Your help can make a difference! Click here to donate.

 

Tom Sullivan
DEF’s Ambassador of Vision
sullivanvision.com

 

 

A Second Vision

Kristin McDonald

For the last few years Kristin McDonald, a former actress and television spokeswoman, has been applying her make-up without the aid of her eyes due to retinitis pigmentosa, a condition that reduces a person’s peripheral vision until all that is left is a pinpoint of sight.

Today, she is in a first stage study that is offering her and others hope that the injection of stem cells might be the mechanism that could slow, and maybe even halt the effects of this horrible disease. Discovery Eye Foundation helped support many of the preliminary translational studies necessary to bring the clinical trial to the FDA and get this exciting, novel approach to the patients.

I am Tom Sullivan, Ambassador of Vision for the Discovery Eye Foundation, and I was rocked when my phone rang recently and I heard the sound of my friend Kristin crying.

“What’s the matter?” I asked with real concern.

Her tears were quickly replaced by laughter, joyous laughter.

“It might be working,” she said, “I mean, the cells just might be having an impact.”

“Meaning your feeling change in your vision?” I asked. 

“Tom,” she went on, “you won’t believe it. This morning when I was getting dressed and putting on my make-up, I saw my mascara in the mirror. Listen, I am not trying to tell you I can see, but since the cells were injected, I can focus on a light and even begin to notice shadows.”

“And, now,” she laughed again, “maybe I can put my mascara on straight!”

Kristin has no illusions about how far the injection of cells will take her; but, she is encouraged, as are many of the other patients who are part of Dr. Henry Klassen’s clinical study helped by DEF’s early stage funding.  Maybe the old phrase really does apply – you probably know the one I mean – “hope springs eternal in the human breast.” That goes for the researchers, the patients, and all of us who treasure the gift of sight.

To read more about Kristin McDonald, visit her website at secondvision.net

 

Tom Sullivan
DEF’s Ambassador of Vision
sullivanvision.com

Get Fit for Your Vision

It’s no secret that exercise is the best way to get in shape and to prevent serious health conditions. But did you know that you can actually exercise your way to healthy eyes too!?

Like your heart, brain, and lungs, your eyes are impacted by how you care for your body. By eating a healthy diet and exercising regularly, you can help prevent eye conditions linked to obesity and being out of shape.

Studies have found connections between regular exercise and reducing risks for several common eye ailments such as cataracts, age-related macular degeneration and glaucoma. Vision problems and eye disease also stem from high blood pressure and high cholesterol. A healthy diet and regular exercise are two of the most important steps you can take to lower both.

 

What you should know about the common eye diseases and exercise

Cataracts – Studies have found that a lack of physical activity may be associated with an increased risk of getting cataracts. Whether it’s a brisk walk around your block or a run through the park, both activities may be associated with decreased risk of age-related cataract.

Age-related Macular Degeneration (AMD)– Studies found that that those who were active and exercised three or more times a week were less likely to develop AMD.

Glaucoma – Doctors treat glaucoma by lowering high intraocular (eye) pressure. Research that focused on young adults found that moderate intensity, low-impact exercise led to significant reduction in eye pressure. Regular, ongoing exercise, such as walking or jogging, will help reduce eye pressure.

 

How to kick off your exercise routine

  • Start simple and set realistic goals. Keep a log of your goals and daily exercise routine, this will help you stick to your plan and track your progress.
  • Keep it fun.
  • Mix up your fitness routine with combinations of strength and cardio.
  • Not feeling all that motivated? Try jump-starting your fitness routine with a little Zumba or ballroom dancing; these are super fun ways to get in shape.
  • Head outside and roller skate, bike, or go on a hike—all are great calorie burners too.
  • If it’s too cold to go outdoors, pick up the latest yoga fitness DVD and create a calming atmosphere in your living room. Or you could try a circuit training fitness DVD for a more upbeat cardio workout.
  • Don’t get stuck in a rut: change up your routine frequently to get the biggest bang out of your exercise time!

No time for exercise? You can squeeze it in between everyday tasks such as:

  • Taking the stairs at work instead of the elevator.
  • Walking to your co-worker’s desk instead of sending an e-mail.
  • Doing lunges or squats while brushing your teeth.
  • Contracting and holding your abs while working on your computer – try for 10 contractions every hour.
  • Taking the dog for a long walk or jog—try doing a few lunges on the trail.

Stay active, get plenty of exercise and keep a healthy diet. When you’re tempted to slack off, or quit exercising all together, just remember how terrific you’ll look and feel when you keep moving. You’ll probably agree it’s worth working out a few minutes each day to reap the rewards of good health and great vision!

Click here for Eye Healthy Recipes.

Who’s On First For My Eye’s

The Difference Between an Optometrist and an Ophthalmologist

There are a number of players on your eye-health team, among them your optometrist and your ophthalmologist. It’s not always obvious, however, what position each plays and when you should call on which professional. 

 

Optometrists 

An optometrist holds a doctor of optometry (OD) degree. An optometrist generally completes a four-year college program in the sciences, plus four years of postgraduate professional training in optometry school.

Optometrists examine eyes for vision and health problems, and correct refractive errors with glasses and contact lenses. Some optometrists also provide low vision care and vision therapy. In the United States, optometrists may prescribe medications to treat certain eye problems and diseases, and their scope of care can differ by state. While not licensed to perform eye surgery, optometrists can play a role in pre- and post-operative care, if you have eye surgery performed by an ophthalmologist.

 

Ophthalmologists

An ophthalmologist is a medical doctor (MD) or a doctor of osteopathic medicine (DO), who specializes in eye and vision care. Ophthalmologists complete four years of college, four years of medical school, one year of internship and at least three years of residency in ophthalmology. Some ophthalmologists also have one or two years of additional training to become specialists in cornea, retina, glaucoma, oculoplastics, pediatrics or neuro-ophthalmology.

Ophthalmologists perform eye exams, diagnose and treat diseases, prescribe medications and perform eye surgery. They also prescribe corrective lenses.

 

Which one do I call?

Both optometrists and ophthalmologists perform routine eye exams, and are both trained to detect, diagnose and manage eye diseases. Both can prescribe corrective lenses, and both must fulfill continuing education requirements to maintain their licenses.

If your eyes are healthy, which type of professional to see is a matter of personal preference. If you already have a medical eye problem, such as diabetes, or a family history of AMD or glaucoma, you should consider seeing an ophthalmologist. While most optometrists offer medical treatment for common eye problems and chronic eye diseases, such as pink eye, dry eye or allergies, certain eye disorders require treatment by an ophthalmologist, particularly if you need surgery, laser therapy or other specialized care.

In some cases, your optometrist and ophthalmologist may work as a team. In such a setup, the optometrist is the equivalent of your primary-care doctor, who monitors your ongoing condition and care, and the ophthalmologist is your specialist, who manages your condition medically and/or performs surgery. For routine care, you may want to check with your insurance provider to see which, if either, professional they cover and for what services.

Eye Healthy Foods for the Holidays

Sharing meals with family and friends is one of the major highlights of the holiday season. Whether you treat yourself to old recipes or you try new ones, consider adding these eye-healthy foods to your holiday feast!

LEAFY GREEN VEGETABLES

Be sure to start your holiday meal with a salad, it’s an excellent way to ensure that you and your guests get plenty of zeaxanthin and lutein, two nutrients that help protect your central vision. Adding kale, spinach, or romaine lettuce to salads helps your eyes absorb damaging blue light, combats the effects of cigarette smoke and pollution, and also decreases your risk of developing age-related macular degeneration (AMD), a condition that affects the macula, the part of your retina responsible for central vision. You will also find lutein in grapes, kiwis, broccoli, peas, corn, Swiss chard, and collard greens. 

TURKEY AND BEEF

Turkey and lean beef, two of the main ingredients in many holiday meals, keep your eyes strong and healthy. Both foods are high in zinc, a nutrient important to the retina and the choroid layer under the retina. Zinc is essential for good night vision. Eating foods that are high in the nutrient can also reduce your risk of cataracts and AMD. Other foods that contain zinc include pork, dairy products, chick peas, black-eyed peas, crab, oysters, beans, spinach, mushrooms, cashews, and almonds. 

CARROTS

It wasn’t an old wives tale, it is true Carrots are good for your eyes! They contain beta carotene, a substance that turns into vitamin A when eaten. Eating carrots can benefit your night vision and could possibly reduce your risk of cataracts, AMD, and dry eyes. Other foods that contain beta carotene include pumpkin, sweet potatoes, and butternut squash. All great ingredients to include into your holiday feast. 

FISH

Fish contain omega-3 fatty acids, which can reduce your risk of developing AMD, dry eye, and glaucoma. Salmon, mackerel, flounder, tuna, halibut, herring, and sardines would be a great addition to your holiday meals.
 

WHOLE GRAINS

Whole grains reduce your risk of heart disease, obesity, and type 2 diabetes and can also decrease your risk of AMD. Substituting whole grain flour for white flour in holiday breads and muffins is a simple way to boost your whole grain intake. Other good whole grain sources include wild rice, brown rice, popcorn, oatmeal, bulgur, barley, buckwheat, and couscous. 

FRUIT

Fruits high in vitamin C, such as strawberries and oranges, also offer important vision benefits. Vitamin C is an antioxidant, a substance that can prevent cell damage caused by free radicals. Vitamin C-rich foods help keep the collagen in your cornea healthy and reduce the risk of cataracts and AMD. You can also find vitamin C in grapefruit, kiwi, blueberries, peas, broccoli, and tomatoes.

Sensible food choices, along with regular eye examinations, can help you protect your vision. For eye healthy recipes, visit our EYE COOK section in our website.

Happy Eating and Happy Holidays!