5 Most Common Eye Problems

Most people have eye problems at one time or another. Some are minor and will go away on their own, or are easy to treat at home. Others need a specialist’s care. Some eye issues come with age while others may be a serious condition.

 

If you’ve never had a problem with your eyes it can be easy to forget how important it is to take care of them. The good news is that it’s never too late to start taking care of your eye health. Regular eye health appointments and eye exams can lead to early diagnosis. This is key to correcting or slowing most eye conditions.  Always see your eye care professional if your vision problem lasts for more than a few days or worsens.

The five most common eye conditions leading to loss of vision or blindness are:

  • Dry Eye
  • Cataracts
  • Diabetic retinopathy
  • Glaucoma
  • Age-related macular degeneration

Dry Eye

Dry eye is a common condition that occurs when your tears aren’t able to provide adequate lubrication for your eyes. Tears can be inadequate for many reasons. For example, dry eyes may occur if you don’t produce enough tears or if you produce poor-quality tears. Dry eyes can also feel very uncomfortable.

Signs and symptoms, which usually affect both eyes, may include:

  • A stinging, burning or scratchy sensation in your eyes
  • Stringy mucus in or around your eyes
  • Sensitivity to light
  • Eye redness
  • A sensation of having something in your eyes
  • Difficulty wearing contact lenses
  • Difficulty with nighttime driving
  • Watery eyes, which is the body’s response to the irritation of dry eyes
  • Blurred vision or eye fatigue

Cataracts

A cataract is a clouding of the lens in the eye that typically will affect your vision. Most cataracts are related to aging. People who have cataracts often have other vision problems in one or both eyes that accompany the cataract, such as nearsightedness (myopia), farsightedness (hyperopia), astigmatism (blurred vision), and/or presbyopia (reading problems).

The lens lies behind the iris and the pupil. It works much like a camera lens. It focuses light onto the retina at the back of the eye, where an image is recorded and sent to the brain. The lens also adjusts the eye’s focus, letting us see things clearly both up close and far away. The lens is made of mostly water and protein. The protein is arranged in a precise way that normally keeps the lens clear and lets light pass through it.

But as we age, some of the protein may clump together and start to cloud the lens. This is a cataract. Over time, the cataract may grow larger or more dense making it harder to see. There are no known medications or diets to prevent age-related cataract so currently the only treatment is cataract surgery. Consult an ophthalmologist for a cataract surgery evaluation.

Diabetic Retinopathy

Diabetic retinopathy is the most common diabetic eye disease and a leading cause of blindness in American adults caused by changes in the blood vessels of the retina.

We know that:

  • Currently more than 4 million Americans aged 40 and older have some form of diabetic retinopathy
  • There is a higher prevalence in African Americans, Hispanics/Latinos, American Indians, and Alaska Natives aged 20 and older
  • Preventive measures help and it is highly treatable.

In some people with diabetic retinopathy, blood vessels may swell and leak fluid or blood inside the eye. In other people, abnormal new blood vessels grow on the surface of the retina. The retina is the light-sensitive tissue at the back of the eye. A healthy retina is necessary for good vision.

Two important tips for diabetic retinopathy prevention: 1) Diabetic retinopathy is worse in patients with poor blood sugar control, so follow your diet and medication prescriptions carefully. 2) Get a dilated eye exam from your ophthalmologist every year for early diagnosis and treatment.

Glaucoma

Glaucoma is a disease that causes damage to the major nerve of the eye called the optic nerve, a part of the central nervous system that carries visual information from the eye to the brain.

The eye experiences a gradual increase of intraocular pressure (IOP) due to an imbalance of the fluid produced in the eye and the amount of fluid drained. Over time, elevated IOP can cause vision loss. The most common form of glaucoma is primary open angle glaucoma which affects about 3 million Americans. However, there are other types including narrow angle, congenital, normal tension, and secondary glaucoma.

At age 50 about 2% of the US population has glaucoma, increasing to 4% by age 70 and 10% for those over age 80. While anyone can develop glaucoma, there are some risk factors that increase the likelihood of having this disease, which include:

  • A family history of glaucoma
  • Mexican American heritage over the age of 60
  • African American heritage over age 40.

Often people with glaucoma are unaware they have the disease because there are no symptoms, so it is recommended that you have a dilated eye exam every two years. With early diagnosis there are treatments that can often protect against irreversible damage to the optic nerve that can lead to serious vision loss. Glaucoma can be treated with eye medications, lasers, and various surgical procedures. However, if glaucoma is not controlled can cause debilitating loss of vision.

Age-Related Macular Degeneration

Age-Related Macular degeneration (AMD) is a progressive eye condition affecting as many as 15 million Americans. The disease attacks the macula of the eye, where our sharpest central vision occurs, affecting reading, driving, identifying faces, watching television, safely navigating stairs and performing other daily tasks. Although it rarely results in complete blindness, it robs the individual of all but the outermost, peripheral vision, leaving only dim images or black holes at the center of vision.

As the disease progresses color vision and central vision sharpness deteriorates. the gradual destruction of light sensitive cells continues until large areas are totally gone. Peripheral vision remains, but the ability to clearly see straight ahead and to see color is lost.

For many people, the first sign of macular degeneration is something they notice themselves. Straight lines like doorways or telephone wires may appear wavy or disconnected. When you look at a person, their face may be blurred while the rest of them is in focus. Lines of print may be blurred in the center or the lines may be crooked. For some people, there is a sudden blurring or loss of sight in the center of vision. For any sudden change in vision, you should contact your ophthalmologist immediately.

AMD can be classified into Early AMD and Late AMD. In Early AMD, a patient may have drusen, which are small protein/lipid deposits underneath the retina, and they can still have good vision. In Late AMD, there are two common forms that occur—wet (neovascular AMD) and dry (atrophic AMD). The wet AMD has abnormal blood vessels beneath the retina that leak blood which can greatly distort the vision and cause a central blind spot.  Approximately 10-15% of patients have the wet form. Fortunately, there are treatments for wet AMD.   To date, the dry, atrophic form of AMD does not have any treatments available. In dry AMD, the retinal pigment epithelial (RPE) cells, which are the posterior-most layer of cells in the retina, undergo extensive degeneration that causes the overlying retina to lose function.  We do not know what causes the RPE cells to become unhealthy and start to die.  Many research laboratories worldwide are studying the causes of dry AMD and how to treat it.

Help keep your eyes healthy for years to come with regular eye exams, and treatment at the first sign of a problem.

 

Spring Allergies and Your Eyes

As winter shifts to spring, and flowers, grasses and trees begin to bloom, spring can take a toll on your eyes if you suffer from seasonal allergies. The spring season has a marked an increase in pollen and allergens in the air, that leave you with congestion, headaches, and itchy, swollen eyes, known as eye allergies.

According to the American Academy of Ophthalmology, eye allergies are also called allergic conjunctivitis, and are pretty common. They occur when the eyes react to something that irritates them (called an allergen). The eyes produce a substance called histamine to fight off the allergen. As a result, the eyelids and conjunctiva become red, swollen, and itchy. The eyes can tear and burn. Unlike other kinds of conjunctivitis, eye allergies do not spread from person to person.

What Are the Symptoms of Eye Allergies?

The most common eye allergy symptoms include:

  • red, swollen, or itchy eyes
  • burning or tearing of the eyes
  • sensitivity to light

What are Eye Allergy Triggers?

  • Outdoor allergens, such as pollen from grass, trees, and ragweed
  • Indoor allergens, such as dust mites, pet dander, and mold
  • Irritants, such as cigarette smoke, perfume

Spring Allergy Management

To combat seasonal eye allergies, you must have a dual focus on both prevention and treatment for symptoms.  By making some minor changes to your environment and activities, you can significantly reduce the amount of allergens you come in contact with, and lessen the symptoms you’re experiencing.  Use these seven methods to soothe your eye irritations related to allergies.

  1. Avoid Allergens

The best strategy to minimize your eye discomfort during the spring is to limit your exposure to allergens. As winter comes to an end, create an actionable plan that helps you avoid seasonal allergens like pollen.

Steps you take may include:

    • Changing your HVAC filters before turning on your cooling system for the first time
    • Purchase and use an in-house air purifier
    • Checking pollen levels online as part of your daily routine
    • Cleaning your home more frequently
    • Keeping your windows closed
    • Spring cleaning before the weather actually warms up

These preventative measures are an important first step to good eye health during allergy season.

 

  1. Don’t Wear Contacts

If you are prone to allergy-related eye irritation, stop wearing your contacts for the first month or so of spring weather. While contacts do not cause allergy symptoms, they can aggravate any symptoms that do appear.

You may want to schedule an eye exam, to prepare for switching to full-time glasses use.  This exam presents a good opportunity for you to check that your glasses prescription is current and to make any necessary updates to maintain your comfort and vision quality.

 

  1. Rinse with Sterile Non-Preserved Saline

Eye allergies can cause changes in tear production. Many individuals experience eye dryness or excess tears due to allergies. In some cases, your eyes may water frequently but still feel dry due to allergens.

Much of this type of irritation occurs when airborne allergens come into contact with the surface of the eyeball. To minimize your allergen exposure, rinse your eyes with saline solution. This may reduce the urge to rub your eyes, which is important because rubbing can trigger a release of more histamines and cause redness, swelling, and blood vessel breakage.

 

  1.  Use Non-Preserved Artificial Tear Drops or Medicated Eye Drops

You may also want to use non-preserved artificial tears to help maintain correct eye lubrication. Before you begin a new eye health regimen, consult with your optometrist to determine which brand and formula is best for your symptoms.

In addition to sterile rinses or lubricant eye drops, using medicated eye drops may help relieve some of the discomfort associated with seasonal eye allergies. Decongestant or antihistamine drops can control redness, itchiness, and other symptoms.

 

  1. Try Cold Therapy

Many individuals notice redness, tenderness, and swelling in the eye area when suffering from allergies. Applying cool or cold compresses can provide immediate soothing relief for these symptoms, including improving the appearance of the skin around the eyes.

Use a clean soft cloth or compress designed for use in the eye area. These compresses are gentler than traditional cold therapy tools and are safer for your eyes. Soak the compress in cool water, wring it out, and place over the eyes. You can refresh the compress with water when the cloth no longer feels cold.  To address more intense symptoms, wet your compress, wring out the cloth, and put it in the refrigerator for 10 to 15 minutes. This colder compress will last longer and provide relief for more advanced symptoms.

 

  1. Wash Your Hands and Face Frequently

As mentioned above, many eye allergy symptoms come from allergens landing on the eye. In addition to floating airborne allergens, your eyes could also suffer from contact with allergens that are transferred in on your skin or hair.

Wash your hands more frequently during allergy season. You should also wash your face twice a day and rinse the area around your eyes as needed. These steps reduce the concentration of allergens on your skin. You may also want to pin back any hair that may cover your face at eye height to minimize your allergen exposure.

 

  1. Wear Sunglasses

When you do need to be outside, wear glasses to protect the surface of your eyes from direct contact with allergens. You may prefer to wear sunglasses rather than your usual glasses because most sunglasses have larger lenses than everyday eyeglasses and, therefore, provide more protection.

If you need constant vision correction, but want the benefits of wearing sunglasses, talk to your eye doctor about investing in a pair of high-quality prescription sunglasses.

 

  1. Consult Your Eye Care Professional

If your symptoms continue, consult your eye care professional for help with diagnosis and treatment. There are many prescription medications, not available over the counter, to help control severe allergic symptoms.

 

If your allergies cause vision changes, feelings of a foreign object in your eye, or acute pain, make an appointment as soon as possible.

 

February is AMD/Low Vision Awareness Month

Low vision affects millions of Americans — including many older adults. People with low vision aren’t blind, but because of their vision loss, they may not be able to do everyday tasks like driving or reading even with glasses.

What is Low Vision?

When your eyesight is impaired to the degree that you struggle with daily tasks like reading or cooking – or that you have difficulty recognizing faces, you may have a medical condition referred to as low vision. Someone with low vision can’t simply put on a pair of glasses or contacts and see well; this condition is beyond the typical loss of vision that occurs with aging.

Individuals experiencing low vision can struggle with maintaining independence; hobbies, reading and even socializing may become challenging as vision loss progresses. Because of the impact low vision can have on your life, it is important to have your eyes checked by a low vision specialist if you have any concerns. Since it is unusual to be able to restore vision once it is lost, screenings can help preserve the vision you have and help you access adaptive lenses and devices if you need them. While there is not a cure for low vision,  a low vision specialist can help you adapt and if needed, create a vision rehabilitation program designed to meet your specific needs.

If you are experiencing trouble seeing even with prescription eye glasses, ask your optometrist or ophthalmologist for a low vision evaluation. If your practitioner does not perform this evaluation, request a referral to a low vision specialist in a private practice, at a Braille Institute or a University Eye Care Institute. 

Low vision is often caused by one of these conditions:

  • Age-related macular degeneration (AMD) –AMD is a progressive eye condition affecting as many as 15 million Americans. The disease attacks the macula of the eye, where our sharpest central vision occurs, affecting reading, driving, identifying faces, watching television, safely navigating stairs and performing other daily tasks. Although it rarely results in complete blindness, it robs the individual of all but the outermost, peripheral vision, leaving only dim images or black holes at the center of vision. Read more

  • Diabetes– Diabetic retinopathy is the most common diabetic eye disease and a leading cause of blindness in American adults caused by changes in the blood vessels of the retina.

In some people with diabetic retinopathy, blood vessels may swell and leak fluid or blood inside the eye. In other people, abnormal new blood vessels grow on the surface of the retina. The retina is the light-sensitive tissue at the back of the eye. A healthy retina is necessary for good vision.  Read More 

  • Glaucoma– Glaucoma is a disease that causes damage to the major nerve of the eye called the optic nerve, a part of the central nervous system that carries visual information from the eye to the brain

The eye experiences a gradual increase of intraocular pressure (IOP) due to an imbalance of the fluid produced in the eye and the amount of fluid drained. Over time, elevated IOP can cause vision loss. The most common form of glaucoma is primary open angle glaucoma which affects about 3 million Americans. However, there are other types including narrow angle, congenital, normal tension, and secondary glaucoma. Read more

Reducing your risk for Low Vision

Practicing healthy daily lifestyle habits can reduce your risk for low vision. A healthy diet, not smoking and maintaining healthy blood pressure are important first steps. Other healthy habits that can lower the risk include:

  • Eat a diet with plenty of green, leafy vegetables such as kale, spinach, and collard greens, and fresh fruit.
  • Fish that is high in omega-3 fatty acids is good for eye health. Try to include it in your diet at least once or twice a week. Types of fish that are high in omega-3 fatty acids include salmon, sardines, mackerel, herring, and albacore tuna.
  • It’s important to keep your body healthy. Maintain a healthy weight, exercise regularly, maintain healthy blood pressure and cholesterol levels. The healthier your body, the more it can foster good eye health. Visit our website for eye healthy recipes Eye Cook.
  • Protect your eyes. Wear sunglasses and a hat with a visor in bright sunlight to protect your eyes from potentially harmful ultra-violet (UV) light and blue light.

Low Vision Reading Apps on Your Smartphone

Reading often is one of the most difficult challenges for visually impaired people. Many people with low vision give up reading altogether, because what used to be an enjoyable, effortless activity now requires thought, preparation and a lot of adjustment. In short, reading is just no fun anymore. 

The American Academy of Ophthalmology (AAO) has listed some of the top apps, devices and resources for people with low vision, below are a few listed for reading app, for more apps visit American Academy of Ophthalmology.

Reading

  • KNFB Reader (Android and iOS, $99.99) – This voice-to-text tool lets you take a picture of any text—books, recipes, product labels—and have it read back to you or converted to braille.
  • Audible (Android and iOS, $14.95 per month plus downloads) – Provides downloadable audiobooks, periodicals, newspapers and more. Their collection currently includes 200,000+ books.
  • Kindle app (Android, iOS, PC and Mac, free) – An e-reader app that allows you to download books. Books can be purchased and directly downloaded from Amazon, or downloaded from your library app into the Kindle app. The free Kindle app can be downloaded onto many iOS and Android devices.
  • Bookshare (Android and iOS, $50 per year) – An online library for people with low vision. Currently, the Bookshare collection contains nearly 850,000 titles, downloadable in a choice of formats including ebooks, audio, braille, and large font. Membership requires verification of your print disability, and includes free downloads.
  • BARD Mobile (Android and iOS, free) – A talking book library that offers access to tens of thousands of titles. You must first enroll in the National Library Service (NLS) for the Blind and Print Disabled at the Library of Congress. Note that this program may only be available in the United States.

 

Regular eye exams are essential for all adults; it is recommended that adults over the age of 60 have eye exams each year. If your vision can not be improved to the point that you are able to see the things you need to see or read, your eye care professional can refer you to a low vision specialist. This specialist differs from a conventional optometrist and is trained to evaluate your low vision problem and offer solutions to help you retain or regain independence and the ability to do things you enjoy again.

 

More Low Vision resources

January is Glaucoma Awareness Month

 

Glaucoma is a leading cause of vision loss and blindness in the United States. Glaucoma has no early symptoms — that’s why half of people with glaucoma don’t know they have it. 

The only way to find out if you have glaucoma is to get a comprehensive dilated eye exam. There’s no cure for glaucoma, but early treatment can often stop the damage and protect your vision.   

Anyone can get glaucoma, but those at higher risk include: 

  • Everyone over age 60, especially Hispanics/Latinos 
  • African Americans over age 40 
  • People with a family history of glaucoma 

National Glaucoma Awareness month is important because:

  1. It’s a silent disease – Open-angle glaucoma, the most common type, has no symptoms. Without treatment, those affected will slowly lose their peripheral vision. If glaucoma remains untreated, people may miss objects to the side and out of the corner of their eye.
     
  2. It gives others a voice – National Glaucoma Awareness Month helps patients cope. It’s a time to let them share their stories.
     
  3. It’s important to spread the word – The main objective of this month is to keep people in the know about this disease. Not everyone is aware of how easily they can be affected. Eye care organizations use this month to address the risks and provide treatment tips.

 

Questions for your doctor

If you or a loved one has been diagnosed with glaucoma, you may have lots of questions. Starting treatment early is the best way to stop the damage and protect your vision. Talk to your eye doctor about your symptoms and treatment options.  

Here are a few questions to ask your doctor:

  • What type of glaucoma do I have?
  • How often do I need to get a checkup for my glaucoma?
  • What are my treatment options?
  • What will happen if I don’t get treated for my glaucoma?
  • How will I know if my treatment is working?
  • What are the possible dangers or side effects from treatment?
  • Is there anything I can do to prevent my glaucoma from worsening?
  • Does glaucoma put me at risk for other eye diseases?
  • What can I expect for my vision — now and in the future?
  • Are there any activities I should avoid?

Visiting the doctor can be stressful, especially when you’re dealing with a new diagnosis. It helps to have questions written down ahead of time. 

 

Discovery Eye Foundation is currently funding research to find better treatments for glaucoma. Gifts of any size can make a difference.

Donate Today!

 

Glaucoma simulation video courtesy of NEI

 

 

 

You Can Teach an Old Drug New Tricks

Previously Approved Drug Shows Promise for Dry Age-Related Macular Degeneration (AMD)

Getting FDA approval for new treatments can take years or even decades. But what about repurposing drugs that have already been approved for other diseases? That’s precisely the question DEF-supported researchers are asking about a new treatment for dry age-related macular degeneration (AMD) and other aging diseases, including Alzheimer’s and Parkinson’s.

Six years ago, DEF Research Director Dr. Cristina Kenney began collaborating with Parkinson’s specialist Dr. Howard Federoff of the Department of Neurology at UC Irvine. DEF-supported researchers had previously shown that damaged mitochondria are a significant factor in accelerating cell death in AMD, and Kenney developed a cybrid mitochondria model to study AMD. Federoff had set up a screening system to look at drugs previously approved by the FDA that might improve the health of mitochondria, whose demise also contribute to Parkinson’s and Alzheimer’s. Of more than a thousand drugs screened, he identified 13 that could rejuvenate mitochondria. Kenney’s cell-culture models and Federoff’s system were a match made in research heaven.

Together, the researchers homed in on one drug, which Federoff named PU-91, because it was the 91st drug he’d tested. “When we added PU-91 to our AMD cybrids, the cells lived longer, they functioned better   the damage to the mitochondria was decreased and it really improved the health of the mitochondria,” Kenney says. “PU-91 is a drug called fenofibrate, which has been used for years to treat high cholesterol. When this drug is modified slightly, it helps sluggish mitochondria regain their health. We’re taking a drug that has been used for many years with FDA approval, and we’re repurposing it for a new target and new types of diseases.”

Benefits of Repurposing

After treatment with PU-91, the AMD mitochondria are greatly increased in number and are healthier (green dye). Blue stains nucleus of cells.

Tremendous savings of time and money are to be had by repurposing a known drug rather than starting with a drug people have never used before. Perhaps most importantly, because it’s been used for so many years in patients, the known drug has a proven safety track record. PU-91 has an additional advantage in that it is taken orally. While there is currently one type of treatment for wet AMD — an injection — there is no treatment at all for the dry form of AMD. An oral treatment for dry AMD is a game-changer.

The research is going so well that a company has been formed specifically to bring this drug to market for dry AMD. “As we become more successful, this type of drug can also be used for neurodegenerative diseases that have damaged mitochondria, such as Parkinson’s disease and Alzheimer’s disease,” Kenney says. “Potentially, it might even be used for something, such as glaucoma, that causes cell death of the retina ganglion cells in the eye. There are a lot of potential uses for it.”

Bench to Bedside

DEF currently is supporting ongoing studies to optimize PU-91’s formulations for maximum effectiveness in patients with AMD. “It’s exciting, because this is the goal for translational researchers,” Kenney says. “Take what you’re doing at the bench and bring it to the bedside.”

If you would like to support our sight saving research click here, DONATE NOW

Eye Care Tips for Travelers

Proper eye care is one of the most essential aspects people tend to ignore during, or when planning their travel. The following tips might help you in keeping your eyes healthy when traveling:

1.    Pack accordingly

Pack the following:

    • Lubricating eye drops: Consider packing allergy-specific eye drops that are specially formulated for allergies.
    • Eye wash solution: If you have something in your eye — an eyelash, a fleck of dust — you might be tempted to head to the nearest restroom to wash out your eye with tap water. Stop. That tap water could contain impurities or minerals which may further irritate your eyes or cause an infection. Use a sterile eye wash instead—purchased at your drugstore.
    • Sunglasses and a hat – Goggles if you plan to go swimming
    • Sleep mask

2.   Don’t wear contacts for long-haul trips.

If you’re about to take a long road trip or get on a plane, play it safe by opting for glasses from the start.  Make sure to aim air vents away from your eyes, constant temperature fluctuations and lack of humidity could irritate your eyes.

3.    Apply a warm compress at the end of each leg of the trip

Once you reach your destination, wet a washcloth with warm water and drape it over your eyes for 5-10 minutes. If your eyes feel like they have something in them, try an eye wash solution to irrigate your eyes.

4.   Take steps to manage eye strain.

Eye strain is common, and when you’re a tired traveler, it could get the best of you. The best ways to manage eye strain include limiting screen time and adjusting your lighting, so whether you’re working on your computer or watching in-flight movies, be sure to take frequent breaks. A simple approach is the 20-20-20 rule: Every 20 minutes look away from your screen for 20 seconds and focus on something 20 feet away.

5.    Invest in good sunglasses and wear them

Sunglasses help you avoid glare and air borne foreign particles. They also protect from UV rays. According to the American Academy of Ophthalmology, you should buy glasses that are 100% UV-resistant.  The term “polarized” means they cut glare, not UV rays. AAO recommends buying sunglasses that are large to provide optimal coverage.

Tips for beating dry eyes when traveling

  • Eat a healthy diet of foods that nourish your eyes like Omega 3s and foods rich in Vitamin A. Always make sure you drink plenty of water throughout the day, as this will ensure you stay hydrated.
  • Always make sure you are taking proper care of your contact lenses and putting them in correctly.
  • Wear glasses on a windy day to protect your eyes from becoming dry or irritated. You should also make sure your sunglasses are polarized and filter out 100% of harmful UV rays and block harsh glare off of different surfaces.
  • Avoid areas where there is lots of smoke from fires or cigarettes, as smoke can irritate and make dry eyes feel sore.
  • Make sure you pack lubricating eye drops and medicated eye drops if you require them so that you can treat your eyes immediately when they begin to feel dry. Some users recommend Bausch & Lomb anti-red drops, Lumify.
  • Pack oral allergy medication that will combat any allergies to new pollens or allergens.

These tips will help you take good care of your eyes while traveling.

DEF-Funded Retinitis Pigmentosa(RP) and Age-Related Macular Degeneration(AMD) Projects Converge with Promise

Two hallmark DEF-funded projects are converging, providing great hope for those facing vision loss from retinitis pigmentosa (RP) or age-related macular degeneration (AMD).

The first project, headed by UC Irvine researchers Drs. Henry Klassen and Jing Yang, concentrates on putting human retinal progenitor cells into the eyes of those with RP in order to rescue damaged retinal cells. That project is currently in Phase II clinical trials, progressing toward FDA approval.

                                                      Tissue-culture model

According to DEF Research Director Dr. Cristina Kenney, if the project is approved by the FDA for use with RP, the next question is: What other diseases might these retinal progenitor cells be used for? That’s where a second DEF-funded project comes in.

Kenney is working on a “personalized” cybrid cell model to screen agents that specifically target the mitochondria in AMD cells. To date, the researchers have different cybrid cell lines representing 60 different individuals with eye diseases. They are looking for novel mechanisms to protect AMD cells from dying.

Yang and Kenney are now working together to determine whether the retinal progenitor cells can be the agent that rescues AMD cybrids. “When we take the mitochondria from AMD patients and put them into healthy retinal cells, which makes cybrids, we have shown that these AMD cybrid cells will start to die. So we used that model to ask the question: How do we rescue them?” Kenney says.

Kenney and Yang developed a tissue culture model, where the retinal progenitor cells are grown in one part of a chamber, and the AMD cybrids are grown in another part of chamber, surrounded by culture medium. There is a porous separator between the two chambers through which the cells can communicate.

 “We are finding that the retinal progenitor cells produce a factor that protects the AMD cybrids,” Kenney says. “This provides promising evidence that these proprietary retinal progenitor cells that are being tested for treating RP also may be helpful in AMD patients.”

“DEF has been supporting both these retina-related projects for quite some time, and it’s very exciting to see them coming together to potentially treat both RP and AMD.”

To help support this sight-saving research, please donate to the Discovery Eye Foundation by clicking button below.

July is UV Safety Awareness Month

According to the American Academy of Ophthalmology, studies show that long-term exposure to bright sunlight may increase the risk of cataracts and growths on the eye, including cancer.

UV rays reflected off sand and water can cause eyes to sunburn, potentially resulting in temporary blindness in just a few hours. In support of UV Safety Month this July, the American Academy of Ophthalmology reminds the public of the importance of shielding eyes from the sun’s harmful rays with 100% UV-blocking sunglasses and broad-brimmed hats.

Here are some tips from the American Academy of Ophthalmology:

  • Don’t focus on color or darkness of sunglass lenses: Select sunglasses that block UV rays. Don’t be deceived by color or cost. The ability to block UV light is not dependent on the price tag or how dark the sunglass lenses are.
  • Check for 100 percent UV protection: Make sure your sunglasses block 100 percent of UV-A rays and UV-B rays.
  • Choose wrap-around styles: Ideally, your sunglasses, either the lenses of the frame, should wrap all the way around to your temples, so the sun’s rays can’t enter from the side.
  • Wear a hat: In addition to your sunglasses, wear a broad-brimmed hat to protect your eyes.
  • Don’t rely on contact lenses: Even if you wear contact lenses with UV protection, remember your sunglasses.

  • Don’t be fooled by clouds: The sun’s rays can pass through haze and thin clouds. Sun damage to eyes can occur anytime during the year, not just in the summertime.
  • Protect your eyes during peak sun times: Sunglasses should be worn whenever outside, and it’s especially important to wear sunglasses in the early afternoon and at higher altitudes, where UV light is more intense.
  • Never look directly at the sun. Looking directly at the sun at any time, including during an eclipse, can lead to solar retinopathy, damage to the eye’s retina from solar radiation.
  • Don’t forget the kids: Everyone is at risk, including children.
  • Protect their eyes with hats and sunglasses. In addition, if possible, try to keep children out of the sun between 10 a.m. and 2 p.m., when the sun’s UV rays are the strongest.

In addition to the proper safety eyewear, regular eye exams for early detection and treatment of eye conditions and diseases are essential to maintaining good vision at every stage of life.

According to the American Academy of Ophthalmology, children with a family history of childhood vision problems should be screened for common childhood eye problems before the age of 5. If eye problems such as visual changes, pain, flashes of light, seeing spots, excessive tearing and excessive dryness occur, they should see an eye doctor. Adults between the ages of 40 to 65 should have an eye exam every two years. Adults over the age of 65 should have an eye exam at least every one to two years.

 

May-Healthy Vision Month

When it comes to our health, we may visit our doctors and nurses regularly to make sure our bodies are healthy. But what about our eyes? They’re not always top of mind, but they’re just as important! May is Healthy Vision Month, an observance coordinated by the National Eye Institute to motivate Americans to make their eye health a priority and educate them about steps they can take to protect their vision.

Here are a few ways you can help protect your vision

  • Get an annual comprehensive dilated eye exam.
  • Know your family’s eye health history. It’s important to know if anyone has been diagnosed with an eye disease or condition, since some are hereditary.
  • Eat right to protect your sight: In particular, eat plenty of dark leafy greens such as spinach, kale, or collard greens, and fish that is high in omega-3 fatty acids such as salmon, albacore tuna, trout, and halibut. Visit Eye Cook for eye healthy recipes.
  • Maintain a healthy weight.
  • Wear protective eyewear when playing sports or doing activities around the home, such as painting, yard work, and home repairs.
  • Quit smoking or never start.
  • Wear sunglasses that block 99 -100 percent of ultraviolet A (UVA) and ultraviolet B (UVB) radiation.
  • Wash your hands before taking out your contacts and cleanse your contact lenses properly to avoid infection.
  • Practice workplace eye safety.

Taking care of your eyes also may benefit your overall health. People with vision problems are more likely than those with good vision to have diabetes, poor hearing, heart problems, high blood pressure, lower back pain and strokes, as well as have increased risk for falls, injury and depression.

In addition to your comprehensive dilated eye exams, visit an eye care professional if you have

  • Decreased vision.
  • Eye pain
  • Drainage or redness of the eye
  • Double vision
  • Diabetes
  • Floaters (tiny specks that appear to float before your eyes)
  • Circles (halos) around light sources or if you see flashes of light

For this Healthy Vision Month, take care of your eyes to make them last a lifetime.

How to Prevent Eye Strain While Working From Home

Working from home has become the new normal for many Americans during this pandemic.  Most are happy without the commute, although working outside the office and in all sorts of strange places, such as bedrooms, backyards, living rooms, has become common place. We’ve had to learn how to work remotely, which in turn means spending a lot more time using computers and smartphones.

Moving out of properly-lit classrooms and offices – and away from ergonomically correct desks – can have long-term effects on our eyes.  Excessive time at a computer screen under the best conditions can lead to symptoms of eye strain.

Eye Strain Symptoms include:

  • Headaches
  • Blurred vision
  • Uncomfortable dry eyes
  • Neck and shoulder pain

To help avoid eye strain, here are few tips for working from home:

  • Record time spent on screens – Most adults age 18 and older spend at least 13 hours each day using digital devices. Extended screen time can cause discomfort and vision difficulties. When working from home, you may lose track of how much time you’re on your computer or smartphone.  So keep track of the hours you use devices. That way, you’ll be aware of the demand you’re placing on your eyes.
  • Rest and blink your eyes – Researchers found that over 30% of people using digital devices rarely take time to rest their eyes. Just over 10% say they never take a break, even when working from home. The eye muscles get overworked and don’t get a chance to relax and recover. Experts suggest the 20-20-20 rule; every 20 minutes, focus your eyes and attention on something 20 feet away for 20 seconds.  You can also get up and walk around for a few minutes.

 

  • Reduce exposure to blue light – In the spectrum of light, blue is more high energy and close to ultraviolet light. So, if you use screens throughout the day, ask your eye doctor about the value of computer glasses that block blue light. Reducing exposure to blue light may help lessen vision problems.  At home, using digital devices until bedtime can overstimulate your brain and make it more difficult to fall asleep. Eye doctors recommend no screen time at least one to two hours before going to sleep.

  

  • Sit up straight – Proper posture is important. Your back should be straight and your feet on the floor while you work. Elevate your wrists slightly instead of resting them on the keyboard.

 

 

  • Proper lighting – A setting that’s too bright (sunny backyard) or too dim (cavernous basement) can cause eye strain and headaches. Your screen should be bright enough that you don’t need to squint. A screen shield can help reduce glare.

 

  • Set up monitor properly – Make sure your computer screen is about 25 inches, or an arm’s length, away from your face. The center of the screen should be about 10-15 degrees below eye level.  Cut glare by using a matte screen filter. You can find them for all types of computers, phones, and tablets.  Increase font size or set the magnification of the documents you are reading to a comfortable size.

 

  • Consider computer glasses –For the greatest comfort at your computer, you might benefit from having your eye doctor modify your eyeglasses prescription to create customized computer glasses. This is especially true if you normally wear distance contact lenses, which may also become dry and uncomfortable during extended screen time.  Computer glasses also are a good choice if you wear bifocals or progressive lenses, because these lenses generally are not optimal for the distance to your computer screen.
  • Create Technology-Free Zones – These tips can help reduce eye strain when you’re forced to look at screens all day, creating technology-free zones in certain areas of your home, like the bedroom or bathroom. If you spend the entire day working on the computer, getting in bed and scrolling through social media until you fall asleep won’t do your eyes any favors.

Once you’re done for the day, truly unplug. Read a book or spend some quality time with family members without your phone.

 

  • Get an Eye Exam – If you have tried all these tips and eye strain is still an issue, it might be time to see an eye care professional to schedule an eye exam.  The exam may even detect underlying issues before they becomes worse.