Similar Diseases, Different Locations, Possible Common Treatments
There are many similarities between two age-related diseases (Age-related Macular Degeneration and Alzheimer’s disease) that can affect thousands of people world-wide. In the United States there are 11 million people that have some form of AMD and it is estimated to grow to 22 million by the year 2050. Furthermore, in 2016 it was estimated that the cost to care for those with AMD was $512 billion. Worldwide it is estimated that by 2020, there will be 96 million people with AMD. National Eye Institute
The second aging disorder that causes high degree of damage is Alzheimer’s disease. Presently, in the United States there are 5.4 million people with Alzheimer’s disease and this will increase to approximately 13.8 million by 2050. In 2016, the cost for caring for these patients was $236 billion. Worldwide the numbers of Alzheimer’s patients are estimated to be 44 million and the global cost is $605 billion. Alzheimer’s Association
Similar Risk Factors
The risk factors for both AMD and Alzheimer’s disease are very similar to each other. These include aging, smoking, and high cholesterol. Both diseases are found more frequently in women than men and in approximately 5% to 15% the diseases are found in more than one family member. There is also a genetic risk factor of a lipid transport protein called Apolipoprotein E (ApoE) that provides elevated risk in AMD patients if they carry the allele 2 variant and higher risk in Alzheimer’s patients if they carry the allele 4 variant.
In AMD and Alzheimer’s disease there are 3 events that make the pathologies very similar except that they are found in different locations, either the retina or the brain.
1. Amyloid beta is a protein that is not present in normal tissues but larger quantities accumulate in the brain for Alzheimer’s patients and are identified to be plaques by MRI scans. The presence of these plaques is defining (pathognomonic) for Alzheimer’s disease. In AMD patients amyloid-beta deposits are found to accumulate underneath the retina and form small clumps of protein-lipid materials called drusen. This is significant because the amyloid-beta is very toxic and harmful to the surrounding cells and when it is accumulating in tissues, it causes the cells to be damaged and loss their abilities to function.
2. A second feature of both AMD and Alzheimer’s disease is that there are high levels of tissue damage, loss of function and a lot of cell death in the retina and brain.
3. Finally, both diseases have damage to the mitochondria, which are small units within the cells that are critical to keeping the cells alive. The mitochondria are the “batteries” of the cell providing energy to keep the retina and brain cells functioning. Mitochondria are similar to the batteries in a flashlight. You can have a very expensive flashlight but if you do not have good batteries, the flashlight will not work. It is a similar situation to the cell. As long as the mitochondria are healthy and providing energy the cells can function. However, when the mitochondria start to die, then the cells will lose their functions and cell death will occur. This is true for all types of cells in the body, such as nerve cells, muscle cells, retinal cells, heart cells, etc. In other words, healthy mitochondria are critical to keep cell alive and functioning well.
Future Treatments
Using a novel in vitro model called cybrids (cytoplasmic hybrids), Dr. Cristina Kenney’s laboratory has shown that when mitochondria from patients with AMD are placed into specialized human retinal cells, the AMD mitochondria will cause the cells to die more rapidly than normal because they are so damaged. With this important discovery, the goal of the research group has been to identify drugs and proteins/peptides that can rescue the damage AMD mitochondria and protect the retinal cells. Their research is moving forward very quickly and testing drugs is the top priority for Dr. Kenney’s group. By rejuvenating the mitochondria from ‘old-damage’ to ‘new-healthy’ will prolong the health of the retinal cells and protect vision loss from AMD. What is learned in these studies will have long reaching applications to other aging-diseases such as Alzheimer’s and Parkinson’s diseases.
Many of us just use the basics on our smart phone and never personalize them for our own needs. It is worth taking the time to adjust our phones to take advantage of the special services that may be available and unused. Making a phone call or sending a text message with a smart phone can be challenging, however, with simple modifications, keeping in touch with the world can become a snap. Getting comfortable with your smart phone will make staying in touch with your loved ones very easy.
World KC Day is November 10th! 
Summer is almost over and it’s back to school season. As parents, many of us are busy ensuring our kids are ready and prepared for the new year; worrying about school supplies, new clothes, and new haircuts. There is always a long list of things to do before school starts. But something that often gets overlooked is getting your child’s eyes examined annually.
For example, lutein and zeaxanthin are important antioxidants that help prevent degeneration in the lens and retina. Eating a diet rich in these carotenoids helps reduce the risk of AMD by fighting oxidation in the retinal cells of the eye.
Eating fatty fish, such as salmon, tuna, mackerel, and sardines, that are rich in omega-3 fatty acids also helps lower the risk of AMD. Omega-3 fatty acids are rich in docosahexaenoic acid (DHA), which is important for eye health and visual function. People with dry eye syndrome (i.e., low tear production) can benefit from a diet rich in omega-3 fatty acids because dry eye is linked to low levels of DHA.
Night vision can be impaired not only by the darkness, but also by the sudden glare of lights from oncoming cars, traffic signals, etc. Our eyes are forced to constantly adjust, leaving brief periods of impaired vision between adjustments.
Most problems associated with contact lenses cause minor irritation, but serious eye infections from poor lens hygiene can be extremely painful and may lead to permanent vision loss. About 80 to 90 percent of contact lens-related eye infections are bacterial. A type of infection you can get is called pseudomonas aeruginosa, a fast-growing bacterial infection that can lead to a hole in your cornea. Unfortunately, patients who get this infection have a high chance of permanent scarring and vision loss. Beyond bacteria, fungal infections are also potential threats to your vision.
In a presentation to the American Society of Retina Specialists, Dr. Ajay E. Kuriyan of the University of Rochester reported that three patients who underwent bilateral intravitreal injection of stem-cells for age-related macular degeneration (AMD) suffered bilateral vision loss. The clinic at which all three procedures were performed did not have a licensed ophthalmologist on-site, and the stem-cell injections were administered by a nurse practitioner, Ocular Surgery News reported. Each patient paid $5,000 for the procedure.
It seems like every season is allergy season. In the spring, it’s the tree and flower pollen. Summer adds grass pollen. In the fall, it’s weed pollen. People who have allergies have symptoms such as sneezing, sniffling, and nasal congestion, but allergies can affect the eyes, too. They can make your eyes red, itchy, burning, and watery, and cause swollen eyelids.